Skin aging is a result of the increasingly declining body functions, the slowdown of cell turnover and a decrease in the production of collagen and elastin. Aging occurs due to extrinsic and intrinsic factors. Extrinsic factors are those that come from the environment or from the “outside” of the body and we can control these factors up to a certain level. On the other hand, intrinsic factors are those that come from within us, these factors are related to the way we are genetically determined to age as we grow – we have no control over the intrinsic factors of aging.

External or extrinsic factors, such as smoking or excessive sun exposure, accelerate the skin aging process leading to thickening of the outer-layer of the skin (the epidermis), uneven pigmentation, and wrinkles, among other signs of skin aging. The signs of extrinsic aging can become evident as early as the age of 18, but are usually most visible when we reach the age of 30.

Intrinsic factors are related to the decrease in the production of collagen, elastin, and other proteins in the inner layer of the skin (the dermis). Intrinsic aging affects more than our skin, it leads to weakening of the bones and an overall decrease our body’s functioning capacities.

The signs of aging can we classified as superficial and internal. Superficial changes related to skin aging include:

  • Redness due to the dilation of the skin’s capillaries
  • Dull or lackluster skin
  • Loss of fat underneath the skin, which accentuates wrinkles
  • Loss of skin firmness or tension
  • Appearance of skin spots or discoloration
  • Rough texture
  • Sagging or slack skin
  • Uneven skin tone
  • Wrinkles
  • Dry skin
  • Dehydrated skin

Internal changes related to skin aging include a decrease in:

  • Collagen and elastin production
  • Skin’s ability to bind water or skin dehydration
  • Fat production underneath the skin
  • Blood flow and supply of nutrients to the skin
  • Energy production
  • DNA repair capacity
  • Cell turnover
  • Function of the immune system

The skin can significantly benefit from making healthy lifestyle changes, such reducing the exposure to sunlight, and can even repair some of the damaged caused by extrinsic factors over time.


Cosmetology procedure mesoteraphy. Rejuvenation revitalization, skin nutrition, wrinkle reduction. Doctor making microneedle procedure.Several anti-aging products exist in today’s market. Most of these products, such as cream, serums, and lotions, only have a superficial effect because they are not able to change the way the skin’s cell function and regenerate. Platelet Rich Plasma or PRP is considered an excellent option to reduce the signs of skin aging because it has the ability to regulate the function of skin’s cells.

PRP is obtained from a patient’s blood sample, then it is centrifuged to divide the blood components and to create a solution rich in platelets. This concentrate is injected into the dermis where it stimulates the production of collagen and other proteins, which are essential to maintain a youthful appearance of the skin.

Research shows that PRP increases the amount of a certain type of cells that produce collagen, called fibroblasts, as well as blood vessels in the skin.3 These changes are attributed to the high concentration of growth factors in PRP. Growth factors are small particles that can regulate the growth and regeneration of cells. The overall effect of skin PRP injections is an increase in the production of collagen, which translates in more youthful skin.

A study published in the Actas Dermo-Sifiliográficas Journal in 2017, shows that PRP skin injections can significantly reduce the manifestations of skin aging, including an improvement in wrinkles and elasticity. This study also shows that PRP can decrease the appearance of age spots.3

Another study performed in 2016, shows that PrP injections increase the level of collagen in the skin. According to the authors, even a single application of PRP “could be considered as an effective and safe procedure for facial skin rejuvenation”.4


Cosmetology procedure mesoteraphy. Rejuvenation revitalization, skin nutrition, wrinkle reduction. Doctor making microneedle procedure.

Platelet Rich Plasma is a perfect treatment option for patients seeking natural results. The procedure of PRP injections for skin rejuvenation is considered as very safe because there are no foreign substances such as Hyaluronic Acid or Toxis injected – thus the risk of inflammation or an allergic reaction is minimal. The results of PRP injections for skin rejuvenation can be seen after 3 to 4 weeks.

The procedure can be applied on the:

– Face
– Neck
– Décolleté
– Hands

Independent patient review forums such as list PRP therapy for aesthetic applications, such as skin rejuvenation, among the highest rated. Your doctor will design an individual treatment plan of one or multiple treatments, according to the clinical expectations.

Studies have shown that PRP Therapy for Skin rejuvenation results in

– Skin texture improvement
– Higher skin hydration
– Glow (luminescence) improvements
– Slight volume increase

Ask your doctor if PRP Therapy for the Skin rejuvenation is the right treatment option for you.


Close-up Of Beautician Giving Epilation Laser Treatment On Woman's FaceLaser systems are a popular tool in an aesthetic practice. These systems ablate the skin to kick-start the production of collagen in the skin. Depending on how aggressive the physician sets the parameter of the laser device, the social downtime varies.

PRP applied onto the skin right after the laser procedure has shown to reduce the wound healing, but also improved the cosmetic outcome of the entire procedure3.

Ask your doctor if PRP Therapy post laser treatment is the right treatment option for you.


1Readelli A. Face and neck revitalization with PRP. Clinical out come in a series of 23 consectively treated patients. Journal of Drugs and Dermatology 2010

2Chawla S. Split Face Comparative Study of Microneedling with PRP versus microneedling with Vitamin C in treating atrophic post acne scars. J Cutan Aesth Surgery 2014.

3Cabrera-Ramírez, J.O., Puebla-Mora, A.G., González-Ojeda, A., et al. (2017). Platelet-Rich Plasma for the Treatment of Photodamage of the Skin of the Hands. Actas Dermosifiliogr. Jun 16. pii: S0001-7310(17)30208-9. doi: 10.1016/

4Abuaf, O.K., Yildiz, H., et al. (2016). Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study. Annals of Dermatoly. 28(6):718-724. Epub 2016 Nov 23.



© Copyright 2016. The Content is not intended to be a substitute for professional medical treatment, advice, or diagnosis. Any and all content on without limitation is solely for informational purposes only. Seek medical consultation by a professional doctor regarding any medical question you may have. Reliance on any information provided by is solely at your own risk. None of the statements on has been evaluated by the U.S. FDA or any other regulatory entity. By accessing and using, you agree to accept our Terms of Service and our Privacy Policy. Click2Sell is an authorized reseller of is a service provided by MediNet Infosolutions LLC, 8 The Green, Suite #5371, Dover, DE 19901. Please contact us at